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KMID : 1123920200340050222
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Korean Journal of Oriental Physiology and Pathology
2020 Volume.34 No. 5 p.222 ~ p.228
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Clinical Studies of Acupuncture Treatment for Alzheimer’s Disease Using Neuroimaging Method: A Review of Literature
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Lee Dong-Hyuk
Kim Joo-Hee
Kwon Bo-In
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Abstract
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The purpose of this article was to investigate the current state of studies on clinical trials of acupuncture treatment for Alzheimer’s disease using neuroimaging method. We searched for clinical trials of acupuncture treatment for Alzheimer’s disease(AD) and mild cognitive impairment(MCI) using neuroimaging method in the MEDLINE (Pubmed) database on March 18, 2020. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of acupuncture treatment in AD. Total ten studies were included in this study. The most frequently applied modality for AD was functional MRI. The most frequently selected acupoints for AD were KI3, LR3 and LI4. One of studies showed that acupuncture treatment could improve the symptoms of MCI. Through the analysis, we demonstrated that neuroimaging method could capture the neural substrates associated with AD. Moreover, acupuncture may induce differential response according to the disease status. Finally, real acupuncture could produce more extensive activation/deactivation than sham acupuncture. We hope that neuroimaging method can contribute to the clinical research of acupuncture treatment for AD through large-scale RCT and diverse imaging modality.
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KEYWORD
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Alzheimer’s disease, Mild cognitive impairment, Acupuncture, Review, Neuroimaging
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